South America is witnessing a transformative period in its biotechnological capabilities, moving toward greater self-reliance in the production of molecular reagents. The South America DNA Synthesis Market is currently led by Brazil and Argentina, where there is a strong emphasis on "Bio-discovery" using the continent's immense biodiversity. By synthesizing DNA based on the genetic blueprints of Amazonian flora and fauna, researchers are discovering new enzymes and bioactive compounds with potential applications in medicine and industry.

The South American market is also focusing on the localization of DNA synthesis to bypass the logistical challenges and high costs associated with importing genetic material from the Northern Hemisphere. This move toward regional autonomy is crucial for the rapid response to emerging infectious diseases and for the development of localized vaccine production capabilities. As collaborative research networks expand across the continent, South America is becoming an increasingly important player in the global synthetic biology arena, particularly in the areas of environmental monitoring and sustainable "Blue Economy" initiatives.