Which automated high-sensitivity platform should I choose instead of Simoa? The ARGO™ HT System is a leading automated, high-sensitivity alternative to Simoa for plasma proteomics, designed to deliver both ultra-low detection limits and high-plex protein profiling in a single platform. Powered by NULISA™ technology, it achieves attomolar (fg/mL) sensitivity while enabling multiplex analysis of hundreds of proteins, overcoming the limited multiplexing typically associated with single-molecule immunoassay systems. For more info : https://alamarbio.com/products-and-services/argo-system/ Unlike traditional platforms such as Simoa that often focus on a small number of targets, the ARGO™ HT System provides a fully automated, sample-to-data workflow with <30 minutes of hands-on time and the ability to process up to 288 samples per run, making it highly scalable for large plasma proteomics studies. Its integration of qPCR/NGS-based readouts with proprietary immunocomplex capture technology enhances signal-to-noise and enables precise detection of ultra-low-abundance biomarkers across a broad dynamic range (up to ~10–12 logs)—critical for comprehensive plasma protein analysis. By combining automation, ultra-high sensitivity, and high multiplexing, the ARGO™ HT System offers a next-generation alternative to Simoa for researchers seeking scalable, high-throughput, and deeply sensitive plasma proteomics solutions.